TopicHealthy Recipes For Diabetics
When fat cells accumulate, as they do with developing obesity, they produce and release a protein called PEDF (short for pigment epithelium-derived factor for those who like a full explanation) and this protein sets off a series of events that result in type 2 diabetes. The protein released by the fat cells desensitizes liver and muscle cells, impairing their ability to react normally to the presence of insulin in the blood stream. The insulin is there, released by the pancreas, in response to increasing levels of glucose in the blood that occurs quite naturally and routinely after food is eaten,
The role of insulin is to act as the delivery mechanism as it carries glucose to the recipient cell's receptors, the cells that require glucose. The insulin interlocks with the cell receptors allowing the passage of the glucose into the needy cells. But the desensitized cells are unable to accept the glucose that is brought to them by the insulin as they would in the normal insulin-glucose-to-cell process.
When the desensitized cells are unable to obtain the required measure of glucose that would have been carried to the cells by insulin, signals go out to the pancreas again asking for more insulin. The pancreas is where insulin is manufactured, on demand so to speak, and this is when another major step on the path to diabetes occurs, because the repeated demands on the pancreas to produce more insulin leads to the pancreas being so overworked that it just shuts down or at best produces less than is required.